Investigation of boron nanosized particles prepared with various surfactants and chitosan in terms of physical stability and cell viability

Nanosuspensions (NS) are one of the new generation drug carrier forms developed to overcome deficiencies drugs with poor water solubility or insolubility and considered be most successful approaches formulate compounds in recent years. Boron nitride (BN) is insoluble chemically more stable than carbon, it offers better biological superiority although application carbon structures biomedical field has increased Chitosan a polymer excellent processability biocompatibility thanks its high dielectric constant. In addition, chitosan affinity for metal ions. This study aims combine BN chitosan, which have unique properties, using six different surfactants, investigate their long-term stability use both medicine. this direction, 24 NS formulations were prepared. The 6th 12th months' these studied at +25 °C, 60% relative humidity, +4 °C. Also, prepared evaluated by cell viability test examined terms toxicity. FTIR spectra taken morphologies characterized SEM. Prepared NSs Poloxamer 407 + Tween (N1 - N6) found 6 12 months °C fact that negative zeta potential positive very important antimicrobial activities. low cellular toxicity NSs, especially chitosan-coated higher concentrations shows they enormous diagnosis treatment diseases boron-based future.